An open-source computational and data resource to analyze digital maps of immunopeptidomes

An open-source computational and data resource to analyze digital maps of immunopeptidomes

Blog Article

We present a novel mass spectrometry-based high-throughput workflow and an open-source Oral Pain computational and data resource to reproducibly identify and quantify HLA-associated peptides.Collectively, the resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra, and the analysis of quantitative digital maps of HLA peptidomes generated from a range of biological sources staff by SWATH mass spectrometry (MS).This study represents the first community-based effort to develop a robust platform for the reproducible and quantitative measurement of the entire repertoire of peptides presented by HLA molecules, an essential step towards the design of efficient immunotherapies.